P-Predict

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Prostate Nomogram Application

An app to predict probability of biochemical failure for prostate cancer

Background

Prostate cancer is diagnosed in over 150,000 men every year. With current advances in therapies, patients have longer life e expectancies and prognoses. In 2013, Stoyanova et al developed a nomogram based on machine learning algorithms for predicting the probability of biochemical failure of prostate patients based on key parameters. They are:

  • T-Category

    • T1: The tumor is not detectable with a digital rectal exam (DRE) or imaging but is found in prostate tissue from a biopsy or surgical treatment.
    • T2: The tumor is detectable with a DRE or imaging but is confined to the prostate.
    • T3: Cancer has grown outside the prostate and may have grown into the seminal vesicles.
    • T4: Cancer has grown into other nearby tissues, such as the urethral sphincter, rectum, bladder or wall of the pelvis.

  • Gleason Sum

  • Percent GP 4/5 Percentage of tumor cells with a Gleason pattern of 4 or 5

  • RT Dose The radiotherapy dose measured in Grays

  • PPT Percentage of biopsy tumor that was positive for adenocarcinoma

    Original Nomogram

    The original nomogram was developed in 2013 by Stoyanova et al. Below you will find an image of the orginal

The Digital Application Version

Our app takes the analog version of the nomogram and makes it digital. It is based on a series of regressions from the analog version. Below find an image from the interface.

iOS Version

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Prostate Nomogram for Biochemical Failure

Our biochemical failure nomogram predicts the probability of a patient experiencing biochemical failure after 8 years given information about the prostate tumor, along with information about androgen deprivation therapy. Results from this tool are based on results from large institutions nationwide with large amounts of patient data. Physicians and providers using this tool should discuss the results and meaning of the tool with their patients.

Enter Your Information

All fields are required unless noted optional


What is the T-Category?

(1 to 4)

What is the Gleason Sum?

(6 to 10)


What is the initial (pretreatment) prostate-specific antigen level (iPSA)?

ng/mL (0 to 90)

What is the Percentage of tumor cells with a
Gleason pattern of 4 or 5?

(0 to 100)

What is the radiotherapy dose (in Grays)?

(61 to 90)

What is the percentage of biopsy tumor that was positive for
adenocarcinoma?

(0 to 100)

(Optional) How many months of androgen deprivation therapy (ADT) was the patient on?

(1 to 60)



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The Digital Backend

The backend is based on a series of regressions done in Excel. Please find an example image below.

Resources

Mobile Applications Personalized Medicine